Carcinoma Mucoepidermoide de Glándulas Salivales Intraoral: Factores Clínicos y Patológicos e Inmunoexpresión de c-erbB-2 en 29 Casos. Vanessa Fátima. Abstract. AVILA, Rodolfo Esteban et al. Mucoepidermoid Carcinoma of Salivary Glands: Histological and Inmunohistochemical Prognostic Factors. Publisher: El propósito de este estudio es presentar la casuística del carcinoma mucoepidermoide de glándulas salivales de pacientes diagnosticados en el.

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However, other studies reported a rare expression of c-erbB-2 on these tumors Kernohan et al. All positive cases also expressed cytoplasmic staining.

The effects of carcinoja, gender, anatomic localization, tumor size, clinical stage, histological grade, recurrence, metastasis, compromised surgical margins and treatment on clinicopathological outcomes were investigated. There is no consensus about the best antibody for the evaluation of c-erbB-2 irnmunoexpression Hanna et al.

HER2 expression in salivary gland carcinomas: Through a long follow-up period in present study we could highlight the relevance of primary anatomical site, tumor size and metastasis as useful prognostic factors that may affect survival in patients with a primary diagnosis of head and neck mucoepidermoid carcinomas.

The majority of MEC in minor salivary glands are histologically classified as low grade of malignancy and an association with the c-erbB-2 immunopositivity could be not demonstrated.

Otolaryngol Head Neck Surg. R; Milanezi, E; Olson, S. There have been suggestions that the overexpression of c-erbB-2 on salivary gland tumors is related with histogenesis of these lesions Glisson et al. Although the significance of this cytoplasmic staining remains unknown, Cheng et al.

Low grade tumors seem to arise more often in minor salivary mucoepidermoidee, which according to some authors are detected at earlier stages, probably due to the less aggressive growth in addition to a better visible tumor site. The mucoepidermoid carcinoma mucopeidermoide shows an extremely aggressive pattern for high-grade tumors, whereas its respectivee low-grade counterpart is often indolent and slow-growing.


The OS was defined as the interval between the beginning of the treatment and the date of farcinoma or last information for censored observations.

Rare expression of the c-erbB-2 oncoprotein in salivary gland tumors: The reactions were revealed by applying 0.

Future investigations could benefit from this study, helping to provide further strategies for more efficient management of MECs. Discrepancies were solved by consensus. This antibody although less sensitive than the polyclonal antibody used in other reports Lopes et al. Mucoepidermoid carcinoma MEC is the most common malignant neoplasm of major and minor salivary glands Lopes et al, The medical and surgical records of all cases were reviewed for clinicopathological factors, such as age, gender, primary tumor location, tumor size, clinical stage, histological grade, treatment, compromised surgical margins, tumor recurrence, metastasis, disease-free survival DFS and overall survival OS.

Clinical information about age, gender, and site were obtained from the biopsy records. The disease-free interval for recurrences and metastases ranged from 22 to months and 22 to months, respectively. Coexpression of p53 and c-erbB-2 proteins is associated with histological type, tumour stage, and cell proliferation in malignant salivary gland tumours.

Carcinoma mucoepidermoide

Carcinoma ex pleomorphic adenoma of the salivary gland: A total of 16 cases were analyzed over a period of 18 years; males were The broad age range observed in our series supports that reported in literature. Evaluation of the immunohistochemical staining. There is a wide variation in these malignant mucooepidermoide over different geographic areas and ethnic groups. Few papers evaluating only one type of oral salivary gland tumors are available.


Carcinoma mucoepidermoide de glándulas salivales en Brasil: relación clinicopatológica

Selecting antibodies to detect HER2 overexpression by immunohistochemistry in invasive mammary carcinomas. Our data suggest that further investigation is indeed warranted to better assess the role of c-erbB-2 immunoexpression in pathogenesis of mucoepidermoid carcinomas of salivary glands.

Carcinoma of the parotid and submandibular glands a study of mucoepiderjoide in patients. Blocking of endogenous avidin-botin activity in immunohistochemistry.

Carcinom follow-up period in this ,ucoepidermoide ranged from 6 to months median 65 monthsand the 5 and year OS rates were both The Kaplan-Meier method was used to plot survival curves with the log rank test for analysis of cumulative survival rates. Salivary gland tumors in children and adolescents: In our series the results were similar with 21 Cytoplasmic expression was also observed but not considered in this study as reported in diverse salivary gland tumors Kernohan et al.

Clinicopathologic and immunohistochemical study of intraoral mucoepidermoid carcinoma. The biological features and clinical behavior of mucoepidermoid carcinomas are widely variable and poorly understood. Considering the results in the appraised sample, our findings suggest that some mucoepidermoid carcinoma overexpress c-erbB-2 independent of clinicopathological features such as patient age and gender and site or histological grades of the lesions.