extract of Glycyrrhiza glabra Linn. in aspirin induced ulcer in rats. . The aim of the study was to determine anti ulcer activity of stem bark of. Anti-ulcer activity was evaluated by measuring the ulcer index, gastric content, total Keywords: Anti-ulcer, Cold-restraint, Glycyrrhiza glabra, GutGardTM. The present research has been carried out to investigate antiulcer activity of ethanolic extract of Cynodon dactylon, Ocimum sanctum, Glycyrrhiza glabra, Ficus.

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Licorice compounds glycyrrhizin and 18beta-glycyrrhetinic acid are potent modulators of bile acid-induced cytotoxicity in rat hepatocytes. Further pharmacological studies are being undertaken in order to provide more precise elucidation of the action mechanism involved in this activity. It was observed that the hydroalcoholic extract of G.

The formation of gastric mucosal lesions by necrotizing agents such as HCl and ethanol has been reported to involve the depletion of gastric defensive mechanisms, the production of mucus and bicarbonate secretion Omeprazole was most effective; it reduced the ulcer index to Effects of naringenin and quercetin on experimental chronic gastric ulcer in rat studies on the histological findings.

They were fasted for 18 h and then acclimatized to the test environment for 2 h prior to each experiment. Ulcer index was calculated following the method described previously 9. Its pathogenesis is influenced by acid-pepsin secretion, cellular regeneration, mucus secretion, blood flow, mucosal barrier, prostaglandins, epidermal growth 5 and Helicobacter pylori infection 6.

Number of advantages are associated with use of herbal medicines as opposed to pharmaceutical products some of which include include reduced risk of side effects, effectives with chronic conditions, lower cost, widespread availability.


Author information Article notes Copyright and License information Disclaimer. Submucosal venules constriction lead to stasis of blood flow in mucosal microcirculation, subsequently cause plasma leakage from the vascular bed, contributing to the widespread mucosal injury in this model. The purpose and value of LD50 determinations.

Chemicals and solvents Cimetidine, omeprazole, and indomethacin were purchased ylycyrrhiza Sigma Sigma Chemical Co. Abstract Glycyrrhiza glabra L. Increased macrophage glutathione content reduces cell-mediated oxidation of LDL and atherosclerosis in apolipoprotein E-deficient mice.

Although the etiology of gastric ulcers is still debated, it is accepted that ulcers are caused due to imbalances in mucosal aggressive and self-protective factors. Cimetidine, omeprazole, and indomethacin were purchased from Sigma Sigma Chemical Co.

Results and Discussion Acute oral toxicity It was observed that the hydroalcoholic extract of G. Higher doses of hydroalcoholic extract of G.

Preventive anti-ulcer activity and toxicity of the leaf crude extract. It should be emphasized that the doses that displayed antiulcer activity are much lower than the LD However, studies are needed to prove the safety of its use, as well as the analysis of acute toxicity is fundamentally important to identify the doses that could be used, and to reveal the possible clinical signs caused by the extract.

Swiss mice were randomly divided into six groups, fasted before the experiment, but had free access to water.

Anti-ulcer activity of aqueous and ethanolic extracts of Glycyrrhiza glabra L. in rats.

Hence, it is assumed that flavonoids may contribute at least in part to the antiulcer effect of the plants. Use of combination of herbal drugs proved that these are effective alternatives for chemical drugs.


Hypothermic restraint stress ulcer The experiment was performed by the method of Sairam et al. Second it accumulates in immune cells, causing a reduction of cellular oxidative stress by reducing NADPH oxidase activation and increasing cellular glutathione Y, M, et al. Antiulcer adtivity of Sapindus saponaria L. It seems that two mechanisms may be involved in possess of this property by glabridin: Ulcer index and preventive acticity of each of the groups was calculated using standard methods as described above.

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Anti Ulcer Activity Of Aloevera And Glycyrrhiza Glabra In Swiss Albino Rats |

Open in a separate window. Can’t read the image? Received Feb; Actviity Jun. Besides, being a popular food additive, licorice is also one of the most widely used medicinal herbs in Iran.

The creation of ethanol-induced gastric lesions is of multifactorial origin with decrease in gastric mucus amount as one of the actvity factors. This has resulted in a decline in duodenal ulcers almost always associated with H pylori infection and an increase in gastric ulcers the main site of ulcers caused by NSAIDs.

Oral administration of absolute ethanol produced multiple mucosal lesions in the mice stomach. In addition, the acute toxicity and LD 50 were evaluated.