Cogan-Reese syndrome is a clinical variant of iridocorneal endothelial (ICE) syndrome (see this term) characterized by variable iris atrophy, pigmented and. This variant of ICE syndrome is distinguised by its Cogan-Reese sub-type of ICE syndrome. A YEAR-OLD woman was first diagnosed as having iridocorneal endothelial syndrome in She underwent a trabeculectomy in Photographs first.

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Iridocorneal Endothelial Syndrome ICE syndrome is a unique ophthalmic disorder that involves an irregular corneal endothelium that can lead to varying degrees of corneal edema, iris atrophy, and secondary angle-closure glaucoma. Secondary, unilateral angle-closure glaucoma can occur in these patients because of the occlusion of synsrome trabecular meshwork by the abnormal endothelial proliferation or PAS [4].

Sign in to make a comment Sign in to your personal account. Asymmetric endothelial cell loss and atypical endothelial cell syyndrome is typically evident, which appears on a specular photomicrograph as dark, larger than normal endothelial cells, with a bright central spot.

This is dependent on the timing of diagnosis within the disease course, and the success or failure of treatment. Prognosis for patients with ICE syndrome depends on whether the above complications develop. Scheie HG, Yanoff M. Normal OU Cup-to-disc ratio: Glaucoma and iridocorneal endothelial syndrome.

Trabeculectomy is commonly performed, but the success rates are poor and many patients These visual fields represent a significant worsening OS despite having two prior trabeculectomies. Sign in to customize your interests Sign in to your personal account.

This page was last modified on April 19,at ICE syndrome endothelial cells appear as dark areas with central highlights and light peripheral borders, whereas PPMD shows typical vesicles and bands on specular microscopy.

We performed a trabeculectomy surgery for this patient with a well-functioning bleb to reduce the intraocular pressures following failure of topical anti-glaucoma medications.


A Rare Case of Unilateral Glaucoma. Pre-operatively, the patient was given mannitol due to her severely elevated IOP. The Cogan-Reese variant of the ICE syndromes is unique because of the pedunculated, pigmented nevi that present on the iris, in addition to the corneal edema, PAS, and ectropion uveae.

Specular microscopy is an important diagnostic tool, as the corneal endothelium has a characteristic appearance in ICE syndrome patients. Long-term surgical outcomes of patients with glaucoma secondary to the iridocorneal endothelial syndrome. The patient had further corneal decompensation and underwent descemet stripping automated endothelial keratoplasty 1 month after these photos were taken.

Given her persistently elevated pressures and signs of corneal decompensation, the patient underwent a repeat reeese. Whenever a patient with suspected iris nevus syndrome or essential iris atrophy is subjected to glaucoma surgery, a biopsy specimen of the iris should be obtained for histological study.

A Cause of Unilateral Synvrome. The glaucoma tends to be more severe in progressive iris atrophy and Cogan-Reese syndrome.

Cogan-Reese Syndrome. | Cornea | JAMA Ophthalmology | JAMA Network

Privacy policy About EyeWiki Disclaimers. Iridocorneal endothelial syndrome in Thai patients: Purchase access Subscribe to the journal. Cogann underwent an uncomplicated trabeculectomy, and her intraocular pressure was 14mmHg on post-op day POD 1.

All ICE syndromes are sporadic with no known family history of similar processes. Create a personal account to register for email alerts with links to free full-text articles.

She underwent a trabeculectomy in Acetazolamide was restarted, and timolol and prednisolone forte were added. A sector iridectomy, which was cogwn at the time of GDI in our patient, should be considered in order to eliminate the tube being pulled or clogged by ICE-related membranes. Our website uses cookies to enhance your experience. Transmission and Scanning Electron Microscopic examination of these cells has demonstrated a population of well-differentiated cells with epithelial features such as desmosomes, tonofilaments, and microvilli.


Sign in to access your subscriptions Sign in to your personal account. For information about clinical trials sponsored by private sources, contact: Mild cases can be managed with topical hypertonic saline drops and ointments. Medical therapy for glaucoma is usually initiated with aqueous suppressants, including redse blockers, alpha-2 agonists and carbonic anhydrase inhibitors.

In general, glaucoma is one of the leading causes of blindness in the world.

Cogan-Reese Syndrome: A Rare Case of Unilateral Glaucoma

Residents and Fellows contest rules International Ophthalmologists contest rules. ICE syndrome is considered sporadic in presentation, with no consistent association to other ocular or systemic disease, and familial cases have been very rare. A family history usually shows no other affected family members. A cause of unilateral glaucoma.

Progressive growth of endothelium over iris. Purchase access Subscribe now. Register for email alerts with links coggan free full-text articles Access PDFs of free articles Manage your interests Save searches and receive search alerts. Given uncontrolled IOP and worsening visual field deficits in the left eye, a Baerveldt seton implant was placed along with a surgical sector iridectomy to prevent any ICE-associated membranes from pulling the tube forward Figure 3.

Additionally, eversion of the pupil i. Only comments seeking to improve the quality and accuracy of information on the Orphanet website are accepted. Create a free personal account to access your subscriptions, sign up for alerts, and more. A trabeculectomy with antifibrotic agents mitomycin-C or 5-fluorouracil or a glaucoma drainage device aqueous shunt have been found to be effective in controling IOP in ICE syndrome patients. All studies receiving U.